The Early Orgins of Autism (Article

Patricia M. Rodier The Early Origins of Autism, Scientific American, 282/2 (February 2000), 56-63. Survey of several significant recent results: A) autists have large structural deficits in the brains stem (very small facial nuclei; absent superior olives; 0.2mm separation layer vs 1.1mm normal size.); B) these structural deficits imply damage of malfunction in fetal development in the 3rd to 4th week, early enough that most women do not even know they have conceived; C) Thalidomide victims have an incidence of autism some 30 times higher than in the general population; D) the low but significantly higher incidence of autism and autistic signs in families indicates that several genes are involved; E) One of the genes, HOXA1 has been identified.
     For me the most interesting finding is the atrophied facial nucleus. This bundle of neurons controls the facial and cranial nerves, and so is involved in facial expressions. Autists have poor or absent facial expressions; and they cannot read facial expressions in other people. This suggests to me that autists do not experience changes in facial expression that accompany changes in emotion; and so they have no subjective experience to relate to other people’s facial expressions. Thus, they do not respond to changes in facial expression, as normal babies do, and so they do not develop appropriate responses to the signs of emotion in other people. Note that Temple Grandin (an autist who has written a book about her life) remarks that she cannot recognise other people’s emotions - she must calculate or estimate them. She must also select the appropriate response expression (facial or verbal) from a consciously assembled catalogue.
     If the recent discoveries are supported in future research, the implications for understanding the relationship between genome and development are profound. Autists have a brain-stem deficit, which results in a behavioural deficit, which results in incorrect or inappropriate interaction with their environment, which results in incorrect (or unsuitable) response from their environment, and so on. It’s a kind of vicious circle. The deficit is augmented by the lack of environmental clues that might trigger the development that would (at least in part) make up for the deficit! One can generalise this idea to other phenomena quite easily. The basic idea is that the genome and the environment must interact correctly for normal development to take place. If the child is incapable of correct responses to the environment, the environment (ie, other people) will not interact appropriately with it, and so it will miss the environmental cues that guide normal development. There is some support for this hypothesis: eg, Downs syndrome children provided with simplified and exaggerated versions of suitable cues can and do develop much further towards normalcy than do children deprived of these cues. In fact, it seems that if they are provided with suitable cues, they usually reach the low-normal range of intellectual and the normal range of social functioning.  Great article. **** (2000)

Black Holes and Baby Universes (book)

Stephen Hawking Black Holes and Baby Universe (1993) Collected essays and talks on the subjects indicated, and others. Hawking is worth reading. His disability (on which he gives some reflections) forces him to be pithy. He does allow himself the occasional joke, and has obviously read widely. The repetitive nature of the subjects he has been asked to discuss in public makes for some repeated paragraphs (I think he reuses previously written material, as well he should.)  I enjoyed this book a lot. PS: I am one of those who have read his Brief History of Time. **** (2000)

Crazy for You

George Gershwin Crazy for You. (Great Performances, PBS 12 Jan 2000.) Revival at the Paperthin Theatre in New York, 1997ff.  A wonderfully polished version of this entertaining and charmingly silly story. Well-designed costumes, with just the right subtle exaggeration, impeccably timed dance and comic schticks, some of the best songs Gershwin ever wrote, and superior video techniques. One of the pleasures of the play are the allusions to other plays, movies, and songs. **** (2000)

The Sanctuary Sparrow

Ellis Peters The Sanctuary Sparrow (1983) Cadfael #7. A reread. A falsely accused jongleur, Liliwin, seeks sanctuary from the lynch mob. Cadfael eventually puzzles out the real robber/ murderer, and justice, after a fashion, is done. Like all Peters’ Cadfael books, this is a historical romance presented as a detective story. Although the characters show faults as well as virtues, Cadfael and Hugh Beringar (deputy sheriff of Shrewsbury) are a little too good to be true.
     Characterisation is somewhat Dickensian: characters are their quirks and faults and virtues, and little else. Unlike Dickens, Peters gives us very little of the characters’ inner lives, and contents herself with formulaic description. It works. Their language is of course pseudo-archaic, and that works, too. I think the image of the Middle Ages is too sanitised, despite the obvious brutalities. The TV series, because it could use visuals to generate atmosphere, presents a more believable image. This often seems to happen when entertainments are converted to TV. Multi-media are more efficient at creating the necessary sense of a complete world. Novels can do this, too, but romances are not novels; they don’t have the room to create a complete world. Perhaps this fact accounts for the popularity of series, for in a series each volume can add to the picture, and so expand the reader’s image of the fictive world. Very good of its kind. ***

The Malaise of Modernity (book)

Charles Taylor The Malaise of Modernity (1991) I read this over a couple of years, having bought it on the strength of hearing one of the CBC Ideas program that underlies this book. Taylor’s main points are: a) that the modern search for the authentic self is morally good; b) but that it is often understood as mere self-fulfilment, and so degenerates into self-indulgence or narcissism; c) that there will always be a tension between the desire for individual freedom and the need for a supportive community; d) that there is a danger that the search for authenticity will result in an atomistic, fragmented society; e) democracy requires both freedom for the individual to become a fulfilled person, and for the community to find common goals and values.
    It sounds to me very much like an attempt to reframe the Christian message of wholeness and healing into a humanistic ethos, and by and large Taylor succeeds. He does use a lot of words, though, and doesn’t use enough examples. The discussion is often too abstract, which makes the book heavy going - you constantly have to imagine actual situations, and test your image against Taylor’s discussion. Apart from that, it’s an important book, as they say, and should have a positive influence on the debate about self vs society.
     Footnote: Ashley McIsaac, in an interview about his profanity, etc, at a Year 2000 concert, 00-01-12, claimed that it’s his prerogative to do what he desires. He believes that being yourself means doing what you want. He hasn’t understood that promises or contracts are agreements to limit his actions to those he has agreed to. Taylor would hold him up as an example of horrible misunderstanding of what the ethic of authentic self means. *** (2000)

The Meaning of it All (book)

Richard Feynman The Meaning of it All (1963; publ. 1998)  The Dantz lectures at University of Washington. Great stuff., and worth rereading at regular intervals. Feynman can clarify what science is like no one else: The scientific attitude is admission of ignorance; the scientific method is to search for answers, but always knowing that they are wrong in some way that hasn't been discovered yet. Taken with Barrow's discussion of impossibility (Impossibility), and Green's discussions of string theory (The Elegant Universe), we realise that most of what there is we will never know. Sobering thought, and one that should be engraved on every citizen's mind, heart, and soul. Much of the mess we make or the troubles we bring upon ourselves come from the superstition that we can know for sure. Or: the things we can know for sure are often not worth knowing. Feynman also, and better than Dawkins, presents the sense of wonder that infuses the scientist's work. **** (1999)

The Pursuit of Love (book)

Nancy Mitford The Pursuit of Love (1934). Love tragedy, made interesting and touching by very good character drawing. One gets to care about these people, even though one also feels they are more than somewhat silly. But that very silliness is a reason for their endearing charm. They are so very much themselves, that one wishes the Universe weren't quite so hostile to fools. Not that their folly is harmless - they do cause emotional scars - but they are never mean. One cannot forgive meanness, especially when it is perpetrated for the loftiest motives. Such meanness is often recognised by the pomposity of the criminal, a fact which Mitford is very good at demonstrating. *** (1999)